九州大学大学院薬学研究院生理学分野

論文一覧Publications

原著論文

2025年

  • Kato Y, Wu D, Ito T, Atef Y, Ayukawa K, Mi X, Nishiyama K, Nishimura A, Nishida M. Inhibition of TRPC3-Nox2 Complex Formation Ameliorates Skeletal Muscle Atrophy. Antioxidants. (2025) Dec 26;15(1):38. doi: 10.3390/antiox15010038
  • Watanabe S, Tokunaga K, Tanaka Y, Hirose Y, Mishiro-Sato E, Kano K, Sasaki-Tabata K, Kato Y, Nishida M, Shindo N, Ojida A. β‑Fluorovinylsulfonamide as a Highly Reactivity- and Structure- Tunable Electrophile for Covalent Targeting of Proteins. J. Am. Chem. Soc. (2025) doi: 10.1021/jacs.5c07422
  • Nishiyama K, Hinoi E, Kuwamura M, Nabetani T, Hatoya S, Furuya M, Tani H, Nishida M, Azuma Y. Pharmacological inhibition of Na+/Ca2+ exchanger alleviates colitis via modulation of macrophage activity in multiple species. Int Immunopharmacol. (2025) 10:163:115254. doi: 10.1016/j.intimp.2025.115254
  • Su C, Mi X, Ito T, Kato Y, Nishimura A, Nagata R, Mori Y, Nishida M. TRPC6-Mediated Zn2+ Influx Negatively Regulates Contractile Differentiation of Vascular Smooth Muscle Cells. Biomolecules (2025) 15(2): 267. doi.org/10.3390/biom15020267
  • Nishimura A, Nishiyama K, Ito T, Mi X, Kato Y, Inoue A, Aoki J, Nishida M. Ligand-Independent Spontaneous Activation of Purinergic P2Y6 Receptor Under Cell Culture Soft Substrate. Cells (2025) 14(3):216. doi: 10.3390/cells14030216
  • Nishimura A, Tanaka T, Shimoda K, Ida T, Sasaki S, Umezawa K, Imamura H, Urano Y, Ichinose F, Kaneko T, Akaike T, Nishida M. Non-thermal atmospheric pressure plasma-irradiated cysteine protects cardiac ischemia/reperfusion injury by preserving supersulfides. Redox Biol. (2025) 79:103445. doi: 10.1016/j.redox.2024.103445
  • Nishimura A, Ogata S, Tang X, Hengphasatporn K, Umezawa K, Sanbo M, Hirabayashi M, Kato Y, Ibuki Y, Kumagai Y, Kobayashi K, Kanda Y, Urano Y, Shigeta Y, Akaike T, Nishida M. Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice. Nat Commun. (2025) 16(1):276. doi: 10.1038/s41467-024-55661-5

2024年

  • Kato Y, Ariyoshi K, Nohara Y, Matsunaga N, Shimauchi T, Shindo N, Nishimura A, Mi X, Kim SG, Ide T, Kawanishi E, Ojida A, Nakashima N, Mori Y, Nishida M. Inhibition of dynamin-related protein 1-filamin interaction improves systemic glucose metabolism. Br J Pharmacol. (2024) 181(21):4328-4347. doi: 10.1111/bph.16487
  • Kondo M, Nakamura Y, Kato Y, Nishimura A, Fukata M, Moriyama S, Ito T, Umezawa K, Urano Y, Akaike T, Akashi K, Kanda Y, Nishida M. Inorganic sulfides prevent osimertinib-induced mitochondrial dysfunction in human iPS cell-derived cardiomyocytes. J Pharmacol Sci. (2024) 156(2):69-76. doi: 10.1016/j.jphs.2024.07.007
  • Atef Y, Ito T, Masuda A, Kato Y, Nishimura A, Kanda Y, Kunisawa J, Kusakabe T, Nishida M. Diabetic Mice Spleen Vulnerability Contributes to Decreased Persistence of Antibody Production after SARS-CoV-2 Vaccine. Int J Mol Sci. (2024) 25(19):10379. doi: 10.3390/ijms251910379
  • Zhou L, Nishimura A, Umezawa K, Kato Y, Mi X, Ito T, Urano Y, Akaike T, Nishida M. Supersulfide catabolism participates in maladaptive remodeling of cardiac cells. J Pharmacol Sci. (2024) 155(4):121-130. doi: 10.1016/j.jphs.2024.05.002
  • Ariyoshi K, Nishiyama K, Kato Y, Mi X, Ito T, Azuma YT, Nishimura A, Nishida M. Inhibition of Drp1-Filamin Protein Complex Prevents Hepatic Lipid Droplet Accumulation by Increasing Mitochondria-Lipid Droplet Contact. Int J Mol Sci. (2024) 25(10):5446. doi: 10.3390/ijms25105446
  • Aoki H, Shinkai Y, Akiyama M, Yamazaki S, Nishida M, Kumagai Y. Extracellularly secreted cysteine derived from cystine regulates oxidative and electrophilic stress in HepG2 cells. Free Radic Res. (2024) 58(5):323-332. doi: 10.1080/10715762.2024.2350524
  • Yamada S, Hashita T, Yanagida S, Sato H, Yasuhiko Y, Okabe K, Noda T, Nishida M, Matsunaga T, Kanda Y. SARS-CoV-2 causes dysfunction in human iPSC-derived brain microvascular endothelial cells potentially by modulating the Wnt signaling pathway. Fluids Barriers CNS. (2024) 21(1):32. doi: 10.1186/s12987-024-00533-9
  • Cui Q, Shieh M, Pan TW, Nishimura A, Matsunaga T, Kelly SS, Xu S, Jung M, Ogata S, Morita M, Yoshitake J, Chen X, Robinson JR, Qian WJ, Nishida M, Akaike T, Xian M. 2H-Thiopyran-2-thione sulfine, a compound for converting H2S to HSOH/H2S2 and increasing intracellular sulfane sulfur levels. Nat Commun. (2024) 15(1):2453. doi: 10.1038/s41467-024-46652-7
  • Nishiyama K, Kato Y, Nishimura A, Mi X, Nagata R, Mori Y, Azuma YT, Nishida M. Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression. Int J Mol Sci. (2024) 25(4):2401. doi: 10.3390/ijms25042401
  • Nishimura A, Zhou L, Kato Y, Mi X, Ito T, Ibuki Y, Kanda Y, Nishida M. Supersulfide prevents cigarette smoke extract-induced mitochondria hyperfission and cardiomyocyte early senescence by inhibiting Drp1-filamin complex formation. J Pharmacol Sci. (2024) 154(2):127-135. doi: 10.1016/j.jphs.2023.12.008

2023年

  • Kasamatsu S, Nishimura A, Alam MM, Morita M, Shimoda K, Matsunaga T, Jung M, Ogata S, Barayeu U, Ida T, Nishida M, Nishimura A, Motohashi H, Akaike T. Supersulfide catalysis for nitric oxide and aldehyde metabolism. Sci Adv. (2023) 9(33):eadg8631. doi: 10.1126/sciadv.adg8631.
  • Ogawa A, Ohira S, Kato Y, Ikuta T, Yanagida S, Mi X, Ishii Y, Kanda Y, Nishida M, Inoue A, Wei FY. Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction. Commun Biol. (2023) 6(1):511. doi: 10.1038/s42003-023-04888-x.
  • Nishiyama K, Ariyoshi K, Nishimura A, Kato Y, Mi X, Kurose H, Kim SG, Nishida M. Knockout of Purinergic P2Y(6) Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis. Int J Mol Sci. (2023) 24(4):3800. doi: 10.3390/ijms24043800.
  • Tang X, Nishimura A, Ariyoshi K, Nishiyama K, Kato Y, Vasileva EA, Mishchenko NP, Fedoreyev SA, Stonik VA, Kim HK, Han J, Kanda Y, Umezawa K, Urano Y, Akaike T, Nishida M. Echinochrome Prevents Sulfide Catabolism-Associated Chronic Heart Failure after Myocardial Infarction in Mice. Mar Drugs. (2023) 21(1):52. doi: 10.3390/md21010052.
  • Numaga-Tomita T, Shimauchi T, Kato Y, Nishiyama K, Nishimura A, Sakata K, Inada H, Kita S, Iwamoto T, Nabekura J, Birnbaumer L, Mori Y, Nishida M. Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post-ischaemic blood flow recovery. Br J Pharmacol. (2023)180(1):94-110. doi: 10.1111/bph.15942.

2022年

  • Kato Y, Nishiyama K, Man Lee J, Ibuki Y, Imai Y, Noda T, Kamiya N, Kusakabe T, Kanda Y, Nishida M. TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation. Int J Mol Sci. (2022) 24(1):102. doi: 10.3390/ijms24010102.
  • Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y, Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress. Redox Biol. (2022) 57:102514. doi: 10.1016/j.redox.2022.102514.
  • Oda S, Nishiyama K, Furumoto Y, Yamaguchi Y, Nishimura A, Tang X, Kato Y, Numaga-Tomita T, Kaneko T, Mangmool S, Kuroda T, Okubo R, Sanbo M, Hirabayashi M, Sato Y, Nakagawa Y, Kuwahara K, Nagata R, Iribe G, Mori Y, Nishida M. Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors.Nat Commun. (2022) 13(1):6374. doi: 10.1038/s41467-022-34194-9.
  • Tokuyama T, Uosaki H, Sugiura A, Nishitai G, Takeda K, Nagashima S, Shiiba I, Ito N, Amo T, Mohri S, Nishimura A, Nishida M, Konno A, Hirai H, Ishido S, Toshizawa T, Shindo T, Takada T, Kinugawa S, Inatome R, Yanagi S. Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation. iScience. (2022) 25(7):104582. doi: 10.1016/j.isci.2022.104582.
  • Yamada S, Noda T, Okabe K, Yanagida S, Nishida M, Kanda Y. SARS-CoV-2 induces barrier damage and inflammatory responses in the human iPSC-derived intestinal epithelium. J Pharmacol Sci. (2022) 149(3):139-146. doi: 10.1016/j.jphs.2022.04.010.
  • Shimauchi T, Numaga-Tomita T, Kato Y, Morimoto H, Sakata K, Matsukane R, Nishimura A, Nishiyama K, Shibuta A, Horiuchi Y, Kurose H, Kim SG, Urano Y, Ohshima T, Nishida M. A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia. Cells. (2022) 11(13):2041. doi: 10.3390/cells11132041.
  • Iwata Y, Nakade Y, Kitajima S, Yoneda-Nakagawa S, Oshima M, Sakai N, Ogura H, Sato K, Toyama T, Yamamura Y, Miyagawa T, Yamazaki H, Hara A, Shimizu M, Furuichi K, Mita M, Hamase K, Tanaka T, Nishida M, Muramatsu W, Yamamoto H, Shichino S, Ueha S, Matsushima K, Wada T. Protective effect of d-alanine against acute kidney injury. Am J Physiol Renal Physiol. (2022) 322(6):F667-F679. doi: 10.1152/ajprenal.00198.2021.
  • Murata R, Watanabe H, Nosaki H, Nishida K, Maeda H, Nishida M, Maruyama T. Long-acting thioredoxin ameliorates doxorubicin-induced cardiomyopathy via its anti-oxidative and anti-inflammatory action. Pharmaceutics (2022) 14(3):562. doi: 10.3390/pharmaceutics14030562.
  • Hirata N, Yamada S, Yanagida S, Ono A, Yasuhiko Y, Nishida M, Kanda Y. Lysophosphatidic acid promotes the expansion of cancer stem cells via TRPC3 channels in triple-negative breast cancer. Int. J. Mol. Sci. (2022) 23(4):1967. doi: 10.3390/ijms23041967.
  • Masuda A, Lee J, Miyata T, Mon H, Sato K, Oyama K, Sakurai Y, Yasuda J, Takahashi D, Ueda T, Kato Y, Nishida M, Karasaki N, Kakino K, Ebihara T, Nagasato T, Hino M, Nakashima A, Suzuki K, Tonooka Y, Tanaka M, Moriyama T, Nakatake H, Fujita R, Kusakabe T. Optimization of SARS-CoV-2 Spike protein expression in the silkworm and induction of efficient protective immunity by inoculation with alum adjuvants. Front Immunol. (2022) 12:803647. doi: 10.3389/fimmu.2021.803647.
  • Nishiyama K, Nishimura A, Shimoda K, Tanaka T, Kato Y, Shibata T, Tanaka H, Kurose H, Azuma YT, Ihara H, Kumagai Y, Akaike T, Eaton P, Uchida K, Nishida M. Redox-dependent internalization of purinergic P2Y6 receptor limits colitis progression. Science Signaling. (2022) 15(716):eabj0644. doi: 10.1126/scisignal.abj0644.

2021年

  • Matsuoka Y, Takahashi M, Sugiura Y, Izumi Y, Nishiyama K, Nishida M, Suematsu M, Bamba T, Yamada KI. Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques. Nat Commun. (2021) 12(1):6339. doi: 10.1038/s41467- 021-26633-w.
  • Marutani E, Morita M, Hirai S, Kai S, Grange R, Miyazaki Y, Nagashima F, Traeger L, Magliocca A, Ida T, Matsunaga T, Flicker D, Corman B, Mori N, Yamazaki Y, Batten A, Li R, Tanaka T, Ikeda T, Nakagawa A, Atochin D, Ihara H, Olenchock B, Shen X, Nishida M, Hanaoka K, Kevil C, Xian M, Bloch D, Akaike T, Hindle A, Motohashi H, Ichinose F. Sulfide catabolism ameliorates hypoxic brain injury. Nat Commun. (2021) 12(1):3108. doi: 10.1038/s41467-021-23363-x.
  • Nishida M, Tsuda M. Astrocytic STAT3 activation and chronic itch require IP3R1/TRPC-dependent Ca2+ signals in mice. J Allergy Clin Immunol. (2021) 147(4):1341-1353. doi: 10.1016/j.jaci.2020.06.039.
  • Yagi-Utsumi M, Tanaka T, Otsubo Y, Yamashita A, Yoshimura S, Nishida M, Kato K. Cold Atmospheric Plasma Modification of Amyloid β. Int J Mol Sci. (2021) 22(6): 3116. doi: 10.3390/ijms22063116.
  • Nishiyama K, Toyama C, Kato Y, Tanaka T, Nishimura A, Nagata R, Mori Y, Nishida M. Deletion of TRPC3 or TRPC6 Fails to Attenuate the Formation of Inflammation and Fibrosis in Non-alcoholic Steatohepatitis. Biol Pharm Bull. (2021) 44(3):431-436. doi: 10.1248/bpb.b20-00903.
  • Azuma YT, Suzuki S, Nishiyama K, Yamaguchi T. Gastrointestinal motility modulation by stress is associated with reduced smooth muscle contraction through specific transient receptor potential channel. J Vet Med Sci. (2021) 83(4):622-629. doi: 10.1292/jvms.20-0490

2020年

  • Shimoda K, Nishimura A, Sunggip C, Ito T, Nishiyama K, Kato Y, Tanaka T, TOzakisaitoh H, Tsuda M, Nishida M. Modulation of P2Y6R expression exacerbates pressure overload-induced cardiac remodeling in mice. Sci Rep. (2020) 10(1):13926. doi: 10.1038/s41598-020-70956-5.
  • Azuma YT and Nishiyama K. Interleukin-19 Enhances Cytokine Production Induced by Lipopolysaccharide and Inhibits Cytokine Production Induced by polyI:C in BALB/c Mice. The Journal of veterinary medical science. (2020) 82(7):891-896. doi: 10.1292/jvms.20-0137
  • Che J, Yamaji N, Miyaji T, Miyani-Ueno N, Kato Y, Shen F R, Ma F J. Node-localized transporters of phosphorus essetial for seed development in rice. Plant Cell Physiol. (2020) 61(8):1387-1398. doi: 10.1093/pcp/pcaa074.

2019年

  • Suhaini Sudi, Tomohiro Tanaka, Sayaka Oda, Kazuhiro Nishiyama, Akiyuki Nishimura, Caroline Sunggip, Supachoke Mangmool, Takuro Numaga-Tomita, and Motohiro Nishida
    TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy.
    Scientific Reports 05 June 2019 DOI:10.1038/s41598-019-46252-2
  • Nishiyama K, Numaga-Tomita T, Fujimoto Y, Tanaka T, Toyama C, Nishimura A, Yamashita T, Matsunaga N, Koyanagi S, Azuma YT, Ibuki Y, Uchida K, Ohdo S, Nishida M
    Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3-Nox2 protein complexs.
    Br J Pharmacol. 2019 Sep;176(18):3723-3738. doi: 10.1111/bph.14777. Epub 2019 Aug 6.
  • Nisimura A, SHimoda K, Tanaka T, Toyama C, Nishiyama K, Shinkai Y, Numaga-Tomita T, Yamazaki D, Kanda Y, Akaike T, Kumagai Y and Nishida M.
    Depolysulidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload
    Science Signaling DOI: 10.1096/fj.201802811R.
  • Numaga-Tomita T, Shimauchi T, Oda S, Tanaka T, Nishiyama K, Nishimura A , Birnbaumer L., Mori Y., and Nishida M. 
    TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN.
    The FASEB Journal 2019 Sep;33(9):9785-9796. DOI: 10.1096/fj.201802811R.

2018年

  • Masuda K, Tsutsuki H, Kasamatsu S, Ida T, Takata T, Sugiura K, Nishida M, Watanabe Y, Sawa T, Akaike T, Ihara H. (2018)
    Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons.
    Biochem Biophys Res Commun. Jan 15;495(3):2165-2170. doi: 10.1016/j.bbrc.2017.12.088.
  • Sunggip C, Shimoda K, Oda S, Tanaka T, Nishiyama K, Mangmool S, Nishimura A, Numaga-Tomita A, Nishida M. (2018)
    TRPC5-eNOS axis negatively regulates ATP-induced cardiomyocyte hypertrophy.
    Front. Pharmacol. May 22;9:523. doi: 10.3389/fphar.2018.00523.
  • Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M. (2018)
    Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.
    Science Signaling Nov 13;11(556). pii: eaat5185. doi: 10.1126/scisignal.aat5185.
  • Parichatikanond W, Nishimura A, Nishida M, Mangmool S. (2018)
    Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells.
    J. Pharmacol. Sci. Nov;138(3):184-191. doi: 10.1016/j.jphs.2018.09.007.
  • Ihara H, Kakihana Y, Yamakage A, Kai K, Shibata T, Nishida M, Yamda KI, Uchida K. (2018)
    2-Oxo-histidine-containing dipeptides are functional oxidation products.
    J. Biol. Chem. Nov 30. pii: jbc.RA118.006111. doi: 10.1074/jbc.RA118.006111.

2017年

  • Oda S., Numaga-Tomita T., Kitajima N., Toyama T., Harada E., Shimauchi T., Nishimura A., Ishikawa T., Kumagai Y., Birnbaumer L. and Nishida M.
    TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice.
    Sci. Rep. Aug 8;7(1):7511 (2017). doi: 10.1038/s41598-017-07903-4.
  • Phosri S., Arieyawong A., Boonrukchai K., Parichatikanond W., Nishimura A., Nishida M. and Mangmool S.
    Stimulation of adenosine A2B receptor inhibits endothelin-1-induced cardiac fibroblast proliferation and α-smooth muscle actin synthesis through the cAMP/Epac/PI3K/Akt-signaling pathway.
    Front. Pharmacol. Jun 30;8:428 (2017). doi: 10.3389/fphar.2017.00428.
  • Shimauchi T., Numaga-Tomita T., Ito T., Nishimura A., Matsukane R., Oda S, Hoka S., Ide T., Koitabashi N., Uchida K., Sumimoto H., Mori Y. and Nishida M.
    TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.
    JCI Insight. Aug 3;2(15). pii: 93358 (2017). doi: 10.1172/jci.insight.93358.
  • Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto T, Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T.
    MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts.
    J Am Heart Assoc. Feb 10;6(2), pii: e003601 (2017). doi: 10.1161/JAHA.116.003601.
  • Yamaguchi Y, Iribe G, Kaneko T, Takahashi K, Numaga-Tomita T, Nishida M, Birnbaumer L, Naruse K.
    TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes.
    J. Physiol. Sci. Jan 19 (2017). doi: 10.1007/s12576-016-0519-3.

2016年

  • Numaga-Tomita T., Kitajima N., Kuroda T., Nishimura A., Miyano K., Yasuda S., Kuwahara K., Sato Y., Ide T., Birnbaumer L., Sumimoto H., Mori Y. and Nishida M.
    TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.
    Sci. Rep. 6, 39383 (2016); doi: 10.1038/srep39383.
  • Kitajima N., Numaga-Tomita T., Watanabe M., Kuroda T., Nishimura A., Miyano K., Yasuda S., Kuwahara K., Sato Y., Ide T., Birnbaumer L., Sumimoto H., Mori Y. and Nishida M.
    TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.
    Sci. Rep. 6, 37001 (2016). doi: 10.1038/srep37001.
  • Unoki T, Abiko Y, Toyama T, Uehara T, Tsuboi K, Nishida M, Kaji T, Kumagai Y.
    Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells.
    Sci Rep., Jun 30;6:28944 (2016). doi: 10.1038/srep28944.
  • Hagimori M, Murakami T, Shimizu K, Nishida M, Ohshima T, Mukai T.
    Synthesis of radioiodinated probes to evaluate the biodistribution of a potent TRPC3 inhibitor.
    Med. Chem. Comm. 7(5), 1003-1006 (2016). doi: 10.1039/c6md00023a.
  • Nishimura A, Sunggip C, Tozaki-Saitoh H, Shimauchi T, Numaga-Tomita T, Hirano K, Ide T, Boeynaems J-M, Kurose H, Tsuda M, Robaye B, Inoue K,Nishida M*.
    The purinergic P2Y6 receptor heterodimerizes with the angiotensin AT1 receptor to promote angiotensin II-induced hypertension.
    Sci. Signal. 9(411), ra7 (2016). doi: 10.1126/scisignal.aac9187.
  • Sawamura S, Hatano M, Takada Y, Hino K, Kawamura T, Tanikawa J, Nakagawa H, Hase H, Nakao A, Hirano M, Rotrattanadumrong R, Kiyonaka S, Mori MX, Nishida M, Hu Y, Inoue R, Nagata R, Mori Y.
    Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds.
    Mol Pharmacol. 89(3), 348-363 (2016). doi: 10.1124/mol.115.102863.
  • Mangmool S, Denkaew T, Phosri S, Pinthong D, Parichatikanond W, Shimauchi T, Nishida M.
    Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner.
    Mol Endocrinol. 30(1), 118-132 (2016). doi: 10.1210/me.2015-1201.
  • Numaga-Tomita T, Nishida M*, Putney JW Jr. and Mori Y*.
    TRPC3 amplifies B cell receptor-induced ERK signaling via protein kinase D-dependent Rap1activation.
    Biochem J. Jan 15;473(2):201-10 (2016). doi: 10.1042/BJ20150596. (*corresponding author)

2015年

  • Gentry LR, Nishimura A, Cox AD, Martin TD, Tsygankov D, Nishida M, Elston TC, Der CJ.
    Divergent Roles of CAAX Motif-signaled Posttranslational Modifications in the Regulation and Subcellular Localization of Ral GTPases.
    J Biol Chem. 290(37), 22851-22861 (2015). doi: 10.1074/jbc.M115.656710.
  • Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y.
    Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress.
    Chem Res Toxicol. 28(5), 838-847 (2015). doi: 10.1021/tx500416y.

2014年

  • Yamada Y, Kinoshita H, Kuwahara K, Nakagawa Y, Kuwabara Y, Minami T, Yamada C, Shibata J, Nakao K, Cho K, Arai Y, Yasuno S, Nishikimi T, Ueshima K, Kamakura S, Nishida M, Kiyonaka S, Mori Y, Kimura T, Kangawa K, Nakao K.
    Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure.
    Cardiovasc. Res. 104(1):183-93 (2014). doi: 10.1093/cvr/cvu185.

2013年

  • Watari K, Nakaya M, Nishida M, Kim KM, Kurose H. 
    β-arrestin2 in infiltrated macrophages inhibits excessive inflammation after myocardial infarction. 
    PLoS One. 8(7):e68351 (2013). doi: 10.1371/journal.pone.0068351.
  • Nakaya M, Tajima M, Kosako H, Nakaya T, Hashimoto A, Watari K, Nishihara H, Ohba M, Komiya S, Tani N, Nishida M, Taniguchi H, Sato Y, Matsumoto M, Tsuda M, Kuroda M, Inoue K, Kurose H.  GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance.
     Nature Commun. 4, 1532 (2013). doi: 10.1038/ncomms2540.
  • Nishida M, Ishikawa T, Saiki S, Sunggip C, Aritomi S, Harada E, Kuwahara K, Hirano K, Mori Y, Kim-Mitsuyama S. 
    Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice. 
    Biochem. Biophys. Res. Commun. 434(2), 210-216 (2013). doi: 10.1016/j.bbrc.2013.03.040.
  • Chen W, Oberwinkler H, Werner F, Gasner B, Nakagawa H, Feil R, Hofmann F, Schlossmann J, Dietrich A, Gudermann T, Nishida M, Del Galdo S, Wieland T, Kuhn M. 
    Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels.
    Arterioscler. Thromb. Vasc. Biol. 33(9), 2121-2129 (2013). doi: 10.1161/ATVBAHA.113.001974.

2012年

  • Nakaya M, Chikura S, Watari K, Mizuno N, Mochinaga K, Mangmool S, Koyanagi S, Ohdo S, Sato Y, Ide T, Nishida M, Kurose H.
    Induction of cardiac fibrosis by β-blocker in G protein-independent and GRK5/β-arrestin2-dependent signaling pathways.
    J. Biol. Chem. 2012 Oct 12;287(42):35669-35677. doi: 10.1074/jbc.M112.357871.
  • Nakaya M, Chikura S, Watari K, Mizuno N, Mochinaga K, Mangmool S, Koyanagi S, Ohdo S, Sato Y, Ide T, Nishida M, Kurose H.
    Induction of cardiac fibrosis by β-blocker in G protein-independent and GRK5/β-arrestin2-dependent signaling pathways.
    J. Biol. Chem. 2012 Oct 12;287(42):35669-35677. doi: 10.1074/jbc.M112.357871.
  • Fujino T, Ide T, Yoshida M, Onitsuka K, Tanaka A, Hata Y, Nishida M, Takehara T, Kanemaru T, Kitajima N, Takazaki S, Kurose H, Kang D, Sunagawa K.
    Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes.
    Mitochondrion. 12:449-458(2012). Epub 2012 Jun 16. doi: 10.1016/j.mito.2012.06.002
  • Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, Akaike T.
    Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration.
    Nature Chem Biol. 8: 714-724 (2012) doi: 10.1038/nchembio.1018. [Epub ahead of print]
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